Case Studies

Impact of pre-therapy glioblastoma multiforme microenvironment on clinical response to autologous CMV-specific T-cell therapy

Our Newro Foundation research team, Prof David Walker, Neurosurgeon and Beth Morrison, Clinical Research & Development Manager, have been working in collaboration with the School of Medicine, QIMR and the Department of Pathology, Hong Kong to research the impact of pre-therapy glioblastoma multiforme microenvironment on clinical response to autologous CMV-specific T-cell therapy.

Cystic tumour of the 3rd Ventricle

A young lady in her early 30s presented to her GP with a short history of headaches and visual disturbance. Over a longer period of time, she had been investigated for infertility. An MRI scan of the brain revealed a large solid and cystic tumour of the 3rd ventricle. It appeared to be compressing the optic chiasm inferiorly and also causing early obstructive hydrocephalus. Below are representative images from the […]

Normal Pressure Hydrocephalus

Mr A is a 67 year old man who presented having been noted by his family as developing memory problems for 2-3 years with deteriorating mobility. On questioning he admitted to a number of episodes of wetting himself and being unsure of how this happened. He underwent a CT and MRI which showed a possible diagnosis of normal pressure hydrocephalus. He was admitted to hospital and had a lumbar puncture […]

Recurrent Glioma – an agonizing choice of approach

A 48 year old man had been followed in our clinic for approximately 5 years. He had previously been treated at another institution after being diagnosed with a malignant glioma after suffering from seizures. After his initial presentation with seizures, he had surgical resection of a small tumour of the right frontal region, and then this was followed with radiotherapy and chemotherapy. He made a reasonable recovery from this. On […]

Microvascular Decompression of the Trigeminal Nerve

Case presentation: A 63 year-old woman presented with a 10-year history of left sided facial pain. Pain was described as over the left maxilla with radiation to the left eye and over the left side of the head. The severe pain was intermittent and described as sharp, shooting and electrical like in nature. It was aggravated by, brushing her teeth, touching her face, eating, drinking, and cold wind. She had […]

Giant Olfactory Groove Meningioma

This 74 year old lady presented with progressive depression. She had been treated medically for months but her symptoms did not improve. She then developed headaches and cognitive deficits such as poor short term memory became increasingly obvious. An MRI scan of the brain was eventually done, revealing a very large lesion of the anterior cranial fossa. Fig 1. Preoperative MRI T1+GAD. A. Axial, B. Sagittal, C. Coronal Surgery proceeded […]

Neck pains and occipital headaches – a rare pathology

A 69 year old male presented to his GP with a slowly progressive, 6 month history of left sided neck pains and occipital headaches. Examination was unremarkable and in particular, strengths and reflexes in all 4 limbs were normal. CT scan revealed some degenerative changes low down in the cervical facet joints and a referral was made to an orthopaedic spinal specialist, and from here facet joint injections were undertaken. […]

Occipital Neuralgia

Occipital neuralgia is a painful condition characterised by pain originating in the upper neck and back of the head. It radiates from the sub-occipital region over the top or side of the head and behind the eyes. Pain is described as paroxysmal shooting or stabbing in the dermatomes corresponding to the lesser and greater occipital nerves. Hypo- or dysaesthesia in the affected area can accompany the pain. The main symptom […]

Haemangioblastoma

This 43 male presented with progressive headaches and neck pain over many months. He also described some visual obscuration over that time. He had a CT scan without contrast and was referred for assessment. An MRI scan was performed, showing a large, highly vascular left sided posterior fossa tumour, with obstructive hydrocephalus (figs 1 and 2). Urgent treatment of the hydrocephalus was needed so he proceeded to an endoscopic 3rd […]

Chiari Malformations: A Curious Pathology

Chiari malformation (CIM) presents an interesting pathology, affecting both children and adults. It is described as a downward displacement of the cerebellar tonsils through the foramen magnum (Fig 1). This downward displacement of the cerebellar tonsils (more than 5-7mm below the foramen magnum) is the primary cause of signs and symptoms observed. This herniation can be a result of congenital or acquired malformations. There are several theories yet to be […]

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